First Nyerges lab preprint
Proud and excited to share the Nyerges lab’s first preprint, in which we:
- create a high-fitness firewalled organism,
- that stably colonizes the mouse gut for >100 days,
- resists all tested bacteriophages in the gut,
- and blocks horizontal gene transfer.
Plus a new method: chimera genome generation to tailor existing synthetic recoded genomes for a wide range of useful applications, including safe gut-colonizing living therapeutics in this work and biocontained, genetically firewalled organisms for environmental bioremediation, cancer therapy, and industrial bioproduction in the future.