Welcome!
I am an NIH/NIBIB-funded Principal Investigator at Harvard Medical School. My work focuses on genome synthesis and genetic code engineering for virus resistance, biocontainment, and the production of genetically encoded unnatural polymers. Prior to Harvard, as a Boehringer Ingelheim Fonds Ph.D. Fellow, I developed synthetic biology tools for directed evolution and genome engineering and utilized these tools for rational antibiotic design and development. During my undergraduate research, I developed a broad-host-range genome editing system that is now widely used for microbial genome engineering. Most recently, I received a K99/R00 Award from the US National Institute of Biomedical Imaging and Bioengineering, with which I am working on the clinical translation of my recent discoveries.
More about my research & publications.
We merge genome & genetic code engineering with drug development & directed evolution to enable therapeutic and industrial applications that are not attainable with existing cell-based systems and biopolymers.
Intermolecular interactions of a nonstandard amino acid within an aminoacyl-tRNA synthetase enzyme. The rational engineering of these interactions paves the way for novel, genetically encoded biopolymers, protein and peptide drugs, and enables tight - potentially escape-free - biocontainment for living organisms and their engineered genetic information.
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